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A modular synthesis of dithiocarbamate pendant unnatural α-amino acids

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http://cfpub.epa.gov/si/si_public_comments.cfm

Citation:

Saha, A., N. Baig, J. Leazer, AND R. Varma. A modular synthesis of dithiocarbamate pendant unnatural α-amino acids. CHEMICAL COMMUNICATIONS. Royal Society of Chemistry, Cambridge, Uk, 48(71):8889-8891, (2012).

Impact/Purpose:

Sent for publication in the Royal Society of Chemistry (RSC) Journal, Chemical Communication

Description:

Unnatural α-amino acids containing dithiocarbamate side chains were synthesized by a one-pot reaction of in-situ generated dithiocarbamate anions with sulfamidates. A wide range of these anions participated in the highly regio- and stereo-selective ring opening of sulfamidates to produce the corresponding dithiocarbamate pendant α-amino acids in high yields.

Record Details:

Record Type:DOCUMENT( JOURNAL/ PEER REVIEWED JOURNAL)
Product Published Date:06/29/2012
Record Last Revised:08/09/2012
OMB Category:Other
Record ID: 245451