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Method development for liquid chromatographic/triple quadrupole mass spectrometric analysis of trace level perfluorocarboxylic acids in articles of commerce
LIU, X., K. KREBS, Z. GUO, AND N. ROACHE. Method development for liquid chromatographic/triple quadrupole mass spectrometric analysis of trace level perfluorocarboxylic acids in articles of commerce. JOURNAL OF CHROMATOGRAPHY A. Elsevier BV, AMSTERDAM, Netherlands, 1216(18):3910-3918, (2009).
An analytical method to identify and quantify trace levels of C5 to C12 perfluorocarboxylic acids (PFCAs) in articles of commerce (AOC) is developed and rigorously validated. Solid samples were extracted in methanol, and liquid samples were diluted with a solvent consisting of 60:40 (v/v) methanol and 2 mN NHtAc aqueous solution [60:40 (v/v) solution]. In both cases, the samples were spiked with an isotopically labeled recovery check standard. The samples were concentrated in nitrogen atmosphere (solid samples only), filtered, and then analyzed by HPLC coupled with tandem mass spectrometer. Method evaluation included selection of extraction solvent for extraction, selection of solvent for preparing injection samples, method comparison for extraction and sample concentration, determination of extraction efficiency, instrument and method detection limits, and determination of potential sample loss during filtration and sample storage. Results of consecutive extractions demonstrated that a single extraction step accounts for 70 to 100% of the "total" PFCAs with the exception of cookware. The instrument detection limits for C5 to C12 were ≤0.05 nglmL, and method detection limits ≤0.4 ngimL. The method has been used to determine the PFCA content in a wide range of AOCs containing or treated with fluoropolymers and fluorotelomers.
URLs/Downloads:NRMRL RTP P 1002.PDF (PDF,NA pp, 238 KB, about PDF)
METHOD DEVELOPMENT FOR LIQUID CHROMATOGRAPHIC/TRIPLE QUADRUPOLE MASS SPECTROMETRIC ANALYSIS OF TRACE LEVEL PERFLUOROCARBOXYLIC ACIDS IN ARTICLES OF COMMERCE Exit
Record Details:Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL RISK MANAGEMENT RESEARCH LABORATORY
AIR POLLUTION PREVENTION AND CONTROL DIVISION
INDOOR ENVIRONMENT MANAGEMENT BRANCH