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TRIMETHOPRIM-SULFAMETHOXAZOLE RESISTANCE IN SEWAGE ISOLATES OF ESCHERICHIA COLI
Boczek*, L A., C H. Johnson*, AND E W. Rice. TRIMETHOPRIM-SULFAMETHOXAZOLE RESISTANCE IN SEWAGE ISOLATES OF ESCHERICHIA COLI. A. Anoruo (ed.), Journal of Environmental Monitoring and Restoration. Society of Advocates for Sustainable Environment, Orangeburg, SC, 2:19-25, (2006).
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Sewage samples from seven locations in the United States were analyzed for Escherichia coli isolates which were resistant to trimethoprim-sulfamethoxazole (SXT). The prevalence rate of SXT resistant organisms varied between the different geographical locales. The majority of the SXT resistant E. coli were also resistant to ampicillin and tetracycline, and exhibited high maximum inhibitory concentration (MIC) values. Resistant isolates were found in phylogenetic groups associated with commensal E. coli (phylogenetic groups A and B1) as well as in those groups associated with extraintestinal infections, including urinary tract infections (UTIs) (phylogenetic groups B2 and D). Serogrouping indicated that serogroups most often assoicated with UTIs were found primarily in the B2 and D phylogentic groupings. These findings suggest that commensal E. coli isolates may serve as a potential reservoir of antibiotic resistance. Studies of sewage isolates conducted over time may assist in determining indigenous levels of antibiotic resistance within a community.