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Multiple Daily Low-Dose Bacillus anthracis Ames Inhalation Exposures in the Rabbit
U.S. EPA. Multiple Daily Low-Dose Bacillus anthracis Ames Inhalation Exposures in the Rabbit. U.S. Environmental Protection Agency, Washington, DC, EPA/600/R-11/145, 2012.
The U.S. EPA, as one of the lead federal agencies supporting decontamination activities after a biological incident, has been systematically evaluating microbial dose-response data and its application for decision making to support decontamination activities. Site-specific risk-based decision making following a biological threat agent release poses extremely difficult and unique challenges, especially for a persistent agent such as Bacillus anthracis. Inhalation exposure risk from B. anthracis spores can result from aerosolized spores during a terrorist attack, subsequent re-aerosolized spores before cleanup takes place, or re-aerosolized residual spores after remediation is complete. The objective of this study was to evaluate physiological responses following 15 inhalation exposures to low doses of B. anthracis Ames spores representative of potential exposures that might be encountered in a reoccupancy/reuse scenario.
URLs/Downloads:Multiple daily low dose Bacillus anthracis Ames inhalation exposures in the rabbit (PDF,NA pp, KB, about PDF)
Record Details:Record Type: DOCUMENT (PUBLISHED REPORT/REPORT)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL HOMELAND SECURITY RESEARCH CENTER
THREAT AND CONSEQUENCE ASSESSMENT DIVISION