Office of Research and Development Publications

A Decision Support Framework for Evaluation of Engineered Nanomaterials

Citation:

Boyes, W. A Decision Support Framework for Evaluation of Engineered Nanomaterials. Americal Public Health Association, Denver, CO, October 29 - November 02, 2016.

Impact/Purpose:

to describe an approach to developing predictive models for assessment of engineered nanomaterials

Description:

Engineered nanomaterials (ENM) are currently being developed and applied at rates that far exceed our ability to evaluate their potential for environmental or human health risks. The gap between material development and capacity for assessment grows wider every day. Transformative approaches are required that enhance our ability to forecast potential exposure and adverse health risks based on limited information such as the physical and chemical parameters of ENM, their proposed uses, and functional assays reflective of key ENM - environmental interactions. We are developing a framework that encompasses the potential for release of nanomaterials across a product life cycle, environmental transport, transformations and fate, exposure to sensitive species, including humans, and the potential for causing adverse effects. Each component of the framework is conceive of as a sequential segmented model depicting the movement, transformations and actions of ENM through environmental or biological compartments, and along which targeted functional assays can be developed that are indicative of projected rates of ENM movement or action. The eventual goal is to allow simple predictive models to be built that incorporate the data from key functional assays and thereby allow rapid screening of the projected margin of exposure for proposed applications of ENM enabled products. In this way, cases where a substantially safe margin of exposure is forecast can be reduced in priority for assessments, and those cases for which no clearly safe margin of exposure is evident can be considered for further evaluations. This abstract does not reflect EPA policy

URLs/Downloads:

ABSTRACT FOR THE AMERICAN PUBLIC HEALTH ASSOCIATION MEETING BOYES.DOCX

Record Details:

Record Type: DOCUMENT (PRESENTATION/ABSTRACT)
Product Published Date: 11/02/2016
Record Last Revised: 11/04/2016
OMB Category: Other
Record ID: 330946

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LABORATORY

TOXICOLOGY ASSESSMENT DIVISION

NEUROTOXICOLOGY BRANCH