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PROTEIN PROFILING OF XENOPUS LAEVIS BRAIN CELLS FOLLOWING EXPOSURE TO T4-SYNTHESIS INHIBITORS: POTENTIAL APPLICATION TO THE ASSESSMENT/DIAGNOSIS OF XENOBIOTICS THAT PERTURB THE THYROID PATHWAY
Citation:
Serrano, J A., B. Witthuhn, L. Higgins, J E. Tietge, J J. Korte, P A. Kosian, G W. Holcombe, AND S J. Degitz. PROTEIN PROFILING OF XENOPUS LAEVIS BRAIN CELLS FOLLOWING EXPOSURE TO T4-SYNTHESIS INHIBITORS: POTENTIAL APPLICATION TO THE ASSESSMENT/DIAGNOSIS OF XENOBIOTICS THAT PERTURB THE THYROID PATHWAY. Presented at Society of Toxicology (SOT) Annual Meeting, New Orleans, LA, March 6-10, 2005.
Description:
To address USEPA's need for a cost effective, non-mammalian screening assay for thyroid axis disrupting chemicals, a multi-endpoint strategy combining molecular and in vivo protocols in an amphibian model is being applied at MED-Duluth. To support the molecular phase goals of this project, this abstract specifically addresses the use of a proteomic approach to assess the effects of a suite of model T4 inhibitors on the thyroid hormone axis of Xenopus Laevis. It is expected that mechanistic data provided in this fashion by both proteomic and genomic endpoints will contribute to elucidate mechanisms of action of thyroid active chemicals.