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PHENOBARBITAL AFFECTS THYROID HISTOLOGY AND LARVAL DEVELOPMENT IN THE AFRICAN CLAWED FROG XENOPUS LAEVIS
Chowdhury, M. J., G W. Holcombe, P A. Kosian, J E. Tietge, AND S J. Degitz. PHENOBARBITAL AFFECTS THYROID HISTOLOGY AND LARVAL DEVELOPMENT IN THE AFRICAN CLAWED FROG XENOPUS LAEVIS. Presented at Society of Toxicology (SOT) Annual Meeting, New Orleans, LA, March 6-10, 2005.
The abstract highlights our recent study to explore endocrine disrupting effects of phenobarbital in the African clawed frog, Xenopus laevis. In mammals, this chemical is known to induce the biotransforming enzyme UDP-glucuronosyltransferase (UDPGT) resulting in increased thyroid hormone glucuronidation and elimination. In this study, we have seen clear effects of pharnobarbital on thyroid histology and larval development of Xenopus tadpoles, indicating that Xenopus tadpoles are also sensitive to its thyroid axis disrupting effects via UDPGT-mediated pathways. The results would add significantly to our mechanistic understanding of phenobarbital effects on amphibian thyroid systems.