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EXPOSURE TO CONCENTRATED AMBIENT PARTICLES (CAPS): REVIEW
Ghio, A J. AND Huang, YuhChin T. EXPOSURE TO CONCENTRATED AMBIENT PARTICLES (CAPS): REVIEW. INHALATION TOXICOLOGY. Taylor & Francis, Inc., Philadelphia, PA, 16(1):53-59, (2004).
Epidemiologic studies support a participation of fine particulate matter (PM) with a diameter of 0.1 to 2.5 microm in the effects of air pollution particles on human health. The ambient fine particle concentrator is a recently developed technology that can enrich the mass of ambient fine particles in real time with little modification. The advantages of concentrators are that the particles produced are "real world" and they allow exposure at pertinent masses. Limitations include variability in both particle mass and composition and some uncertainty over the best statistical approach to analyze the data. Cumulative evidence provided by the body of initial investigation shows that exposures to concentrated ambient particles (CAPs) can be accomplished safely in both humans and animals. Human investigation using the CAPs has shown acute lung inflammation and changes in both blood indices and heart rate variability. Animal studies support a potential pulmonary inflammation, blood changes, alterations of specific cardiac endpoints, and an increased susceptibility of specific models. These studies have helped establish the causal relationship between find particle exposure and adverse health effects in the lung and cardiovascular system. In addition, it appears that specific components in CAPS may differentially affect these tissues.
Record Details:Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LABORATORY
HUMAN STUDIES DIVISION
CLINICAL RESEARCH BRANCH