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EFFECT OF CAGE BEDDING ON TEMPERATURE REGULATION AND METABOLISM OF GROUP-HOUSED FEMALE MICE.
Gordon, C J. EFFECT OF CAGE BEDDING ON TEMPERATURE REGULATION AND METABOLISM OF GROUP-HOUSED FEMALE MICE. COMPARATIVE MEDICINE 54(1):63-68, (2004).
This manuscript examines how methods used to house and study laboratory rodents could affect the variability and quality of toxicological data. The key finding is that there is likely to be more instability in body temperature and metabolism in mice when housed on conventional bedding materials that are ideal from an economic standpoint but do not provide adequate insulative qualities. The migration away from pine wood shavings and use of synthetic bedding and other materials that do not afford adequate insulation could add unnecessary variability in rodent toxicology studies.