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RECONSTRUCTION OF A HUMAN LUNG MORPHOLOGY MODEL FROM MAGNETIC RESONANCE IMAGES
Isaacs, K K., R. T. Burton, J. S. Fleming, AND T B. Martonen. RECONSTRUCTION OF A HUMAN LUNG MORPHOLOGY MODEL FROM MAGNETIC RESONANCE IMAGES. Presented at International Society for Aerosols in Medicine, 2003 International Congress, United Kingdom, July 14-18, 2003.
RATIONALE A description of lung morphological structure is necessary for modeling the deposition and fate of inhaled therapeutic aerosols. A morphological model of the lung boundary was generated from magnetic resonance (MR) images with the goal of creating a framework for anatomically-realistic models of the human airway network.
METHODS: Data visualization software was used to reconstruct the lung volume from a series of transverse MR images collected at many different vertical locations in the lung, ranging from apex to base. The lung model was then built using isosurface extraction techniques.
RESULTS: The lung model provides a flexible geometric description of the lung boundary that can be used in conjunction with a branching airway network model to build an anatomically realistic model of the airway tree.
CONCLUSIONS: These methods may facilitate the creation of customized morphological models for individual experimental subjects, resulting in improved interpretation of aerosol distribution data obtained from single photon emission computed tomography (SPECT) studies. Customized models could also be developed for children and for patients with respiratory diseases, aiding in the study of inhaled drug delivery in these sensitive subpopulations.
DISCLAIMER:This is an abstract of a proposed presentation and does not necessarily reflect EPA policy.