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THE FAILURE OF CHLOROFORM ADMINISTERED IN THE DRINKING WATER TO INDUCE RENAL TUBULAR CELL NEOPLASIA IN MALE F344/N RATS
DeAngelo, A B., M H. George, S. R. Kilburn, AND D. R. Geter. THE FAILURE OF CHLOROFORM ADMINISTERED IN THE DRINKING WATER TO INDUCE RENAL TUBULAR CELL NEOPLASIA IN MALE F344/N RATS. Presented at Society of Toxicology 42nd Annual Meeting, Salt lake City, UT, March 9-13, 2003.
The failure of chloroform administered in drinking water to induce renal tubular cell neoplasia in male F344/N rats
Chloroform (TCM) has been demonstrated to be a renal carcinogen in the male Osborne-
Mendel rat when administered either by corn oil gavage or in drinking water. We examined the ability of TCM in the drinking water to enhance renal tubular cell (RTC) cancer in the Male F344/N rat. Animals (78/group) were exposed to concentrations of 803 +/-5 or 1592 +/-21 mg/L TCM in the drinking water for 100 weeks. Distilled water served as the vehicle control; lead acetate, 2000 mg/L, was the positive control. A complete necropsy was done at 100 weeks. Water consumption did not differ among the groups. Mean daily doses of 53, 126, and 132 mg/kg were calculated for the low and high dose TCM and lead acetate respectively. Mean body weight was significantly depressed by TCM treatments. No RTC tumors were found in the control or in the TCM groups. Lead acetate increased (p = 0.05) the incidence of RTC carcinoma (12.8%), adenoma(10.3%) and hyperplasia (100%) compared to 7.7% for hyperplasia in the control. No RTC hyperplasia was seen in the THM groups. The high TCM dose increased the prevalence (% of animals with a lesion) of hepatocellular neoplasia (carcinoma and adenoma) 17.5% vs 5.1% (p= 0.05) and marginally enhanced the prevalence of combined preneoplastic and neoplastic tumors (20.5% vs 7.7%; 0.05
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Record Details:Record Type: DOCUMENT (PRESENTATION/ABSTRACT)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LABORATORY
ENVIRONMENTAL CARCINOGENESIS DIVISION
CANCER BIOLOGY BRANCH