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Extrapolation of chemical susceptibilities across humans, domesticated animals, wildlife, and plants using the SeqAPASS tool
Citation:
Doering, J. AND C. LaLone. Extrapolation of chemical susceptibilities across humans, domesticated animals, wildlife, and plants using the SeqAPASS tool. SETAC Europe 2019, Helsinki, N/A, FINLAND, May 26 - 30, 2019.
Impact/Purpose:
The One Health Initiative is an effort to improve the lives of all species through integration of human medicine, veterinary medicine, and environmental science. Part of this initiative is to understand how to prevent disease through understanding the effects of medicines across species. US EPA’s Sequence Alignment to Predict Across Species Susceptibility tool (SeqAPASS; https://seqapass.epa.gov/seqapass/) is a web-based application that allows the user to begin to understand how broadly toxicity information may plausibly be extrapolated across species. This is critical, because for a majority of chemicals there is very little, if any, laboratory studies evaluating chemical safety for multiple species. Typically, if toxicity data exists it is available for only a limited number of model organisms (one or a handful of species). The SeqAPASS tool takes available toxicity information for a species and using protein sequence and structural comparisons, makes predictions for chemical susceptibility across hundreds of non-tested species. The purpose of this presentation is to discuss how SeqAPASS may be used to support the One Health Initiative. A specific example will be used to demonstrate the utility of SeqAPASS focusing on a protein in the thyroid axis, thyroid hormone receptor alpha.
Description:
The One Health Initiative is an effort to improve the lives of all species through integration of human medicine, veterinary medicine, and environmental science. Part of this initiative is to understand how to prevent disease through understanding the effects of medicines across species. US EPA’s Sequence Alignment to Predict Across Species Susceptibility tool (SeqAPASS; https://seqapass.epa.gov/seqapass/) is a web-based application that allows the user to begin to understand how broadly toxicity information may plausibly be extrapolated across species. This is critical, because for a majority of chemicals there is very little, if any, laboratory studies evaluating chemical safety for multiple species. Typically, if toxicity data exists it is available for only a limited number of model organisms (one or a handful of species). The SeqAPASS tool takes available toxicity information for a species and using protein sequence and structural comparisons, makes predictions for chemical susceptibility across hundreds of non-tested species. The purpose of this presentation is to discuss how SeqAPASS may be used to support the One Health Initiative. A specific example will be used to demonstrate the utility of SeqAPASS focusing on a protein in the thyroid axis, thyroid hormone receptor alpha.