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in vitro Models if Human Embryonic Mesenchymal Transitions in Morphogenesis
Citation:
Hunter, S., K. Grode, Mitch Rosen, M. Hoopes, S. Jeffay, H. Nichols, AND T. Knudsen. in vitro Models if Human Embryonic Mesenchymal Transitions in Morphogenesis. CSS BOSC, RTP, NC, November 16 - 18, 2016.
Impact/Purpose:
Our ability to predict human developmental consequences produced by exposure to environmental chemicals is limited by the current experimental and computational models. Human heart defects are among the most common type of birth defects and affect 1% of children (~40,000 children) born in the US each year. The potential role of environmental chemical exposure in producing heart defects is unknown and controversial. However, epidemiology studies continue to associate drinking water contaminants and organic solvents with these effects. Valvulo-Septal defects are the most common heart defect in children. One of the critical events in the formation of heart valves and septa is endothelial mesenchymal transition (EndMT) of the endocardial cells in the atrioventricular (AV) cushions. Our goal is to develop computational and experimental models of heart AV cushion morphogenesis.
Description:
Our ability to predict human developmental consequences produced by exposure to environmental chemicals is limited by the current experimental and computational models.Human heart defects are among the most common type of birth defects and affect 1% of children (~40,000 children) born in the US each year. The potential role of environmental chemical exposure in producing heart defects is unknown and controversial. However, epidemiology studies continue to associate drinking water contaminants and organic solvents with these effects.Valvulo-Septal defects are the most common heart defect in children. One of the critical events in the formation of heart valves and septa is endothelial mesenchymal transition (EndMT) of the endocardial cells in the atrioventricular (AV) cushions. Our goal is to develop computational and experimental models of heart AV cushion morphogenesis.