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Use of Putative Adverse Outcome Pathways for Chemical Hazard Identification
Wood, C. AND B. Chorley. Use of Putative Adverse Outcome Pathways for Chemical Hazard Identification. Board of Scientific Counselors, RTP, NC, November 16 - 18, 2016.
This poster will be presented at the Board of Scientific Counselors meeting for the CSS National Research Program in Nov 2016.
The Adverse Outcome Pathway (AOP) framework provides a knowledge infrastructure for evaluating health effects of environmental chemicals. In this work we are examining proof-of-concept issues in the development and prospective application of AOPs in chemical safety. Key outputs include tools for more rapid assembly of AOPs, predictive pathway-based models for screening large chemical sets, and susceptibility biomarkers based on early events in AOPs.