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Impact of Work Task-Related Acute Occupational Smoke Exposures on Select Proinflammatory Immune Parameters in Wildland Firefighters
Adetona, A., O. Adetona, R. Gogal, D. Diaz-Sanchez, S. Rathbun, AND L. Naeher. Impact of Work Task-Related Acute Occupational Smoke Exposures on Select Proinflammatory Immune Parameters in Wildland Firefighters. JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE. Lippincott Williams & Wilkins, Philadelphia, PA, 59(7):679-690, (2017).
The decision whether to perform a prescribed burn balances land use, risk of fire and potential health impacts. Understanding the latter requires a quick non intrusive assay which can be used to monitor the health of those exposed to smoke. This is first study to use blood smears to assess changes in systemic differential leukocyte cell populations following wood smoke exposure from prescribed burn. This research is useful for understanding the mechanisms involved in acute inflammatory responses due to such exposures. In addition, internal dose of PM exposure and its relationship with inflammation was uniquely explored.
Objective: A repeated measures study was used to assess the effect of work tasks on select proinflammatory biomarkers in firefighters working at prescribed burns. Methods: Ten firefighters and two volunteers were monitored for particulate matter and carbon monoxide on workdays, January-July 2015. Before and after work-shift dried blood spots were analyzed for inflammatory mediators using the Meso Scale Discovery assay, while blood smears were used to assess leukocyte parameters. Results: Firefighters lighting with drip-torches had higher cross-work-shift increases in interleukin-8, C-reactive protein, and serum amyloid A compared to holding, a task involving management of fire boundaries. A positive association between interleukin-8 and segmented-neutrophil was observed. Conclusion: Results from this study suggest that intermittent occupational diesel exposures contribute to cross-work-shift changes in host systemic innate inflammation as indicated by elevated interleukin-8 levels and peripheral blood segmented-neutrophils.