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Web-based Interspecies Correlation Estimation (Web-ICE) for Acute Toxicity: User Manual Version 3.3
Raimondo, Sandy, C. Lilavois, AND M. Barron. Web-based Interspecies Correlation Estimation (Web-ICE) for Acute Toxicity: User Manual Version 3.3. U.S. Environmental Protection Agency, Washington, DC, EPA/600/R-15/192, 2016.
Updated user guidance and standard operating procedure for using Web-ICE to estimate sensitivity of untested species, including endangered species
Information on the acute toxicity to multiple species is needed for the assessment of the risks to, and the protection of, individuals, populations, and ecological communities. However, toxicity data are limited for the majority of species, while standard test species are generally data rich. To address data gaps in species sensitivity, the Interspecies Correlation Estimations (ICE) application was developed by the U.S. Environmental Protection Agency (US EPA) and collaborators to extrapolate acute toxicity to taxa with little or no acute toxicity data for a chemical of interest, including threatened and endangered species (Asfaw et al. 2003). Web-based Interspecies Correlation Estimation (Web-ICE) provides interspecies extrapolation models for acute toxicity in a user-friendly internet platform.