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Comparative Chemistry and Toxicity of Diesel and Biomass Combustion Emissions
Gilmour, Ian, Y. Kim, AND M. Hays. Comparative Chemistry and Toxicity of Diesel and Biomass Combustion Emissions. Analytical and Bioanalytical Chemistry. Springer, New York, NY, 407(20):5869-75, (2015).
This is a review based on a lecture Dr. Gilmour presented at the Analytica conference in Munich in March 2014
Air pollution includes a complex mixture of carbonaceous gases and particles emitted from multiple anthropogenic, biogenic, and biomass burning sources, and also includes secondary organic components that form during atmospheric aging of these emissions. Exposure to these mixtures has clear adverse health outcomes as demonstrated by increased morbidity and mortality; yet, disentangling the sources and chemical components responsible for these effects has presented serious chemical, analytical, and bio-analytical challenges. In this presentation, we attempt to look forward and examine how current analytical strategies may be applied for investigating health effects due to complex carbon particle mixtures. Examples of volatility-based toxicology models are introduced, and the feasibility of developing a physiological-based fluid extraction model for hydrophobic organic compounds in the lung is also discussed. Finally, the usefulness of harmonizing advanced carbon particle chemical fingerprinting techniques with health effects related studies will be covered.
Record Details:Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LABORATORY
ENVIRONMENTAL PUBLIC HEALTH DIVISION
CARDIOPULMONARY AND IMMUNOTOXICOLOGY BRANCH