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Sequence alignment to predict across species susceptibility (SeqAPASS): Cross species extrapolation in the 21st century
Citation:
LaLone, C., Dan Villeneuve, D. Lyons, AND G. Ankley. Sequence alignment to predict across species susceptibility (SeqAPASS): Cross species extrapolation in the 21st century. International Symposium on Chemical Pollution and Environmental Healt, Nanjing, Jiangsu, CHINA, October 18 - 21, 2015.
Impact/Purpose:
not applicable
Description:
An objective of the U.S. Environmental Protection Agency is to develop innovative approaches and decision support tools for the safety assessment of current and emerging chemicals in relation to their impact on the environment. To support this goal, there is a compelling need for novel, quantitative, scientifically-based approaches to evaluate and predict species differences in susceptibility to various types of chemical contaminants particularly when testing resources are limited and/or rapid turn-around is required. Within the Agency, high-throughput screening (e.g., EPA’s ToxCast program) is enhancing the efficiency of toxicity testing. Therefore, with this innovative technology it is necessary to have methods in place to define the taxonomic domain of applicability as a means to extrapolate data across species and to aid in understanding relevant molecular initiating events across species as they relate to the adverse outcome pathway (AOP) conceptual framework.