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Does obesity increase susceptibility to ozone? Respiratory, behavioral, and metabolic assessments in Brown Norway rats
Gordon, C., A. Johnstone, P. Phillips, U. Kodavanti, AND K. Jarema. Does obesity increase susceptibility to ozone? Respiratory, behavioral, and metabolic assessments in Brown Norway rats. Presented at Society of Toxicology Meeting, Phoenix, AZ, March 23 - 27, 2014.
This abstract will be presented at the Society of Toxicology meeting March 23-27, 2014 in Phoenix, Arizona
There may be a link between obesity and susceptibility to the respiratory, cardiovascular, and other health effects of air pollutants. Furthermore, it has been proposed that some air pollutants are obesogenic and may contribute to obesity. In view of the epidemic growth of obesity and type II diabetes, it is imperative to develop animal models to study the links between obesity, metabolic syndrome, and exposure to air pollutants. Male, 3 month-old rats were fed control, high fat (60% of calories), or high fructose (60% of calories) diets. Percent body fat was monitored every 2 wk using a Bruker 190 minispec. Rats were then exposed to filtered air (FA) or 1 ppm ozone (03) for 6 hr, 1 d/wk for 4 wk. Food consumption was assessed following 03 exposure. After 4 months, both diets led to increases in %body fat (3% for high fat; 1.5% for high fructose) and impaired glucose tolerance. Body weight was similar for the high fat and control rats, but lower for high fructose rats. O led to impaired respiratory responses measured in Buxco chambers. Enhanced Pause (penH) assessed 1 d post-exposure rose significantly but diet had no effect. Body fat was reduced by 2% after 3 weeks of 03 in all diet groups. Exposure to FA also led to significant reductions in body fat and net fat loss was greatest in the control group. Motor activity measured 1 d after 03 was significantly reduced in the control diet group but not high fat or high fructose groups. Food intake of high fat group increased significantly following 03. Housing rats for 6 hr in the Hinner exposure chambers appears to have led to a stress-induced decrease in body fat, a response accentuated by 03. Increasing %body fat by treatment with high fat/high fructose diets failed to alter respiratory susceptibility to 03. The increase in food consumption of high fat animals may indicate an obesogen-like effect of 03. This is an abstract of a proposed presentation and does not reflect US EPA policy.