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Developmental Toxicity of Louisiana Crude Oiled Sediment to Zebrafish
Barron, M., CrystalR Jackson, J. Krzykwa, Becky Hemmer, AND Sandy Raimondo. Developmental Toxicity of Louisiana Crude Oiled Sediment to Zebrafish. Presented at International Symposium on Polycyclic Aromatic Compounds, Corvallis, OR, September 08 - 12, 2013.
Determine dose response relationships between oil in sediment and fish development
Embryonic exposures to polycyclic aromatic hydrocarbons (PAHs) and petroleum products cause a characteristic suite of developmental defects in a variety of fish species. We exposed zebrafish embryos to sediment mixed with laboratory weathered South Louisiana crude oil. Oiled sediment exposures caused a reproducible set of developmental malformations in zebrafish embryos including yolk sac and pericardial edema, hemorrhaging, craniofacial and spinal defects, and tissue degeneration. Dose-response studies showed that total PAH concentrations of 23 mg/Kg (dry weight, 1% organic carbon normalized; 0.6% oil in sediment) caused a significant increase in defects, and 58 mg/Kg caused nearly complete embryo mortality (1.5% oil in sediment). This study demonstrated that oiled sediment is an exposure pathway to fish that can affect embryogenesis consistent with PAH mediated developmental toxicity.
Record Details:Record Type: DOCUMENT (PRESENTATION/ABSTRACT)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LABORATORY
GULF ECOLOGY DIVISION