You are here:
Patterns of clinical bioindicators in rat serum following acute exposure to pesticides of different chemical classes
Citation:
Herr, D., N. Stewart, D. Lyke, Kathy Mcdaniel, AND V. C. Moser. Patterns of clinical bioindicators in rat serum following acute exposure to pesticides of different chemical classes. Presented at Society of Toxicology, March 10 - 14, 2013.
Impact/Purpose:
This abstract will be presented at the Society of Toxicology meeting, March 10-14, 2013, San Antonio, TX
Description:
There is interest in bioindicators of adverse outcomes in safety assessment and translational research. Chemically-induced neurological effects may be reflected in specific neuronal changes and/or by general stress-like responses, and such bioindicators may be useful for measuring health impacts. We examined differential profiles of clinical bioindicators after acute treatment (po) with different pesticides (permethrin, deltamethrin, fipronil, imidacloprid, carbaryl, triadimefon). These same rats were evaluated for EEG changes (Lyke et al., Toxicologist, 2010, 2011, 2012, 2013). Rats were sacrificed after EEG testing. Serum samples were processed by Myriad RBM using their RodentMAP® and Rat MetabolicMAP® assays. Depending on the pesticide, 2-18 of 78 analytes were altered, and each pesticide produced a different pattern of changes. Discriminant analysis indicated that these alterations differed in a dose-related manner for each chemical. The data show that acute exposure to different classes of pesticides produced different patterns of changes in clinical bioindicators, which may be analyzed for linkages to biological pathways. This is an abstract of a presentation and does not necessarily reflect EPA policy