Science Inventory

MetaPath: An Electronic Knowledge Base for Collating, Exchanging and Analyzing Case Studies of Xenobiotic Metabolism

Citation:

KOLANCZYK, R. C., P. SCHMIEDER, W. J. JONES, O. G. MEKENYAN, A. CHAPKANOV, S. TEMELKOV, S. KOTOV, M. VELIKOVA, V. KAMENSKA, K. VASILEV, AND G. D. VEITH. MetaPath: An Electronic Knowledge Base for Collating, Exchanging and Analyzing Case Studies of Xenobiotic Metabolism. REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, 63(1):84-96, (2012).

Impact/Purpose:

To document research results.

Description:

A new MetaPath information system was developed through a collaborative effort between the Laboratory of Mathematical Chemistry (Bourgas, Bulgaria), EPA’s Office of Research and Development (NHEERL, MED, Duluth, MN and NERL, ERD, Athens, GA), and EPA’s Office of Chemical Safety and Pollution Prevention (OPP, Arlington VA). Metabolism data plays a critical role in the risk assessment process. Regulatoryauthorities must manage, document and review large amounts of data on metabolism for pesticide chemicals. The MetaPath system serves to store summary information on pesticide metabolism and environmental degradates that is obtained from the expert reviews of submitted regulatory studies in a structure searchable manner that will increase efficiency of information retrieval in the pesticide program, and allow critical analysis and interpretation of data in a manner currently not possible.

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Product Published Date: 06/01/2012
Record Last Revised: 10/10/2012
OMB Category: Other
Record ID: 240130

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LABORATORY

MID-CONTINENT ECOLOGY DIVISION

MOLECULAR & CELLULAR MECHANISMS RESEARCH