Citation:

MOSER, V. C. Triadimefon. 3rd, Chapter 98, Wexler, P. (ed.), Encyclopedia of Toxicology. Elsevier Science, New York, NY, 4:807-809, (2014).

Impact/Purpose:

A physiologically based pharmacokinetic (PBPK) model was recently developed for triadimefon in rats, with extrapolation to human equivalent doses based on the rat no-effect levels. The authors suggest reverse metabolism from triadimenol back to triadimefon as an explanation for the longer than predicted residence time in tissues.

Description:

Triadimefon (CAS 43121-43-3) is a broad spectrum systemic fungicide. The nervous system is the most sensitive target and serves as the basis for most regulatory assessments. Triadimefon is also a carcinogen and reproductive toxicant at high doses in rodent models.

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