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The importance of data evaluation for PBPK model development and risk assessment application
Citation:
EVANS, M. V. The importance of data evaluation for PBPK model development and risk assessment application. Presented at Society for Risk Assessment Annual meeting, Salt Lake City, UT, December 05 - 08, 2010.
Impact/Purpose:
This talk will stress the importance of ensuring that data inputs are converted correctly, thus leading to an improved version of previous models.
Description:
PBPK models are useful in predicting the toxicologically relevant internal dose for environmental chemicals, and to extrapolate across species and different routes. For volatile organic compounds, PBPK models are usually calibrated using experimental data collected from kinetic experiments intended to establish the link between metabolism and proposed adverse health effects. When using experimental data designed for a different goal than model development, the modeler needs to ensure that original source data (plasma concentration) is appropriately converted to blood concentration for use in the PBPK modeling application. This talk will stress the importance of ensuring that data inputs are converted correctly, thus leading to an improved version of previous models. The process needed to ensure that current versions of PBPK models are included into risk assessments will be discussed. (This abstract does not necessarily reflect EPA policy.)