Science Inventory

Inhibition of Thyroid Hormone Release from Cultured Amphibian Thyroid Glands by Methimazole, 6-Propylthiouracil, and Perchlorate

Citation:

HORNUNG, M. W., S. J. DEGITZ, L. KORTE, J. OLSON, P. A. KOSIAN, A. L. LINNUM, AND J. E. TIETGE. Inhibition of Thyroid Hormone Release from Cultured Amphibian Thyroid Glands by Methimazole, 6-Propylthiouracil, and Perchlorate. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 118(1):42-51, (2010).

Impact/Purpose:

Research results

Description:

The research presented here is the development of an in vitro thyroid gland culture system to test the effect of chemicals directly on the gland without influence of other parts of the HPT axis. . . This information can then be used to select chemicals for further evaluation in vivo if warrented. This model system shows promise as a tool to evaluate the potency of chemicals for inhibiting endpoints of TSH stimulation of the thyroid glands and provides important insights into the in vivo effects of T4 synthesis inhibition on prometamorphic tadpoles.

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Product Published Date: 11/01/2010
Record Last Revised: 08/01/2012
OMB Category: Other
Record ID: 220924

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LABORATORY

MID-CONTINENT ECOLOGY DIVISION

MOLECULAR & CELLULAR MECHANISMS RESEARCH