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The Key Events Dose-Response Framework: A cross-Disciplinary Mode-of-Action Based Approach to Examining Does-Response and Thresholds
Julien, E., A. Bobbis, S. Olin, AND J. PRESTON. The Key Events Dose-Response Framework: A cross-Disciplinary Mode-of-Action Based Approach to Examining Does-Response and Thresholds. Critical Reviews in Food Science and Nutrition. Taylor & Francis Group, London, Uk, 49(8):682-689, (2009).
This paper provides an overview of the Key Events Dose-Response Framework and introduces a series of four companion papers that illustrate initial application of the approach to a range of bioactive agents.
the ILSI Research Foundation conveded a cross-disciplinary working group to examine current approaches for assessing dose-response and identifying safe levels of intake or exposure for four categoreis of bioactive agents: food allergens, nutrients, pathogenic microorganisms, and environmental chemicals. This effort generated a common analytical framework-- the Key Events Dose-Response Framework (KEDRF)-- for systematically examining key events that occur between the initial dose of a bioactive agent and the effect of concernn
Record Details:Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LABORATORY
ASSOCIATE DIRECTOR FOR HEALTH