Science Inventory

The Key Events Dose-Response Framework: A cross-Disciplinary Mode-of-Action Based Approach to Examining Does-Response and Thresholds

Citation:

Julien, E., A. Bobbis, S. Olin, AND J. PRESTON. The Key Events Dose-Response Framework: A cross-Disciplinary Mode-of-Action Based Approach to Examining Does-Response and Thresholds. Critical Reviews in Food Science and Nutrition. Taylor & Francis Group, London, Uk, 49(8):682-689, (2009).

Impact/Purpose:

This paper provides an overview of the Key Events Dose-Response Framework and introduces a series of four companion papers that illustrate initial application of the approach to a range of bioactive agents.

Description:

the ILSI Research Foundation conveded a cross-disciplinary working group to examine current approaches for assessing dose-response and identifying safe levels of intake or exposure for four categoreis of bioactive agents: food allergens, nutrients, pathogenic microorganisms, and environmental chemicals. This effort generated a common analytical framework-- the Key Events Dose-Response Framework (KEDRF)-- for systematically examining key events that occur between the initial dose of a bioactive agent and the effect of concernn

URLs/Downloads:

PRESTON FS&N2.PDF   (PDF,NA pp, 51 KB,  about PDF)

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Product Published Date: 09/01/2009
Record Last Revised: 12/04/2009
OMB Category: Other
Record ID: 210605

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LABORATORY

IMMEDIATE OFFICE

ASSOCIATE DIRECTOR FOR HEALTH