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Thyroid hormone status and pituitary function in adult rats given oral doses of perfluorooctanesulfonate (PFOS)
CHANG, S., J. R. THIBODEAUX, M. L. EASTVOLD, D. J. EHRESMAN, J. A. BJORK, J. W. FROEHLICH, C. LAU, R. J. SINGH, K. B. WALLACE, AND J. L. BUTENHOFF. Thyroid hormone status and pituitary function in adult rats given oral doses of perfluorooctanesulfonate (PFOS) . TOXICOLOGY. Elsevier Science Ltd, New York, NY, 243(3):330-339, (2008).
We hypothesized that exposure to PFOS may increase free thyroxine (FT4) in the rat serum due to the ability of PFOS to compete with thyroxine for binding proteins. The increase in FT4 would increase the availability of the thyroid hormone to peripheral tissues for utilization, metabolic conversation, and excretion. We also hypothesized that PFOS does not directly interfere with the regulatory functions of the hypothalamic-pituitary-thyroid (HPT) axis in rats.
Perfluorooctanesulfonate (PFOS) is widely distributed and persistent in humans and wildlife. Prior toxicological studies have reported decreased total and free thyroid hormones in serum without a major compensatory rise in thyrotropin (TSH) or altered thyroid gland histology. Although these animals (rats, mice and monkeys) might have maintained an euthyroid state, the basis for hypothyroxinemia remained unclear. We undertook this study to investigate the causes for the PFOS-induced reduction of serum total thyroxine (TT4) in rats.
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Record Details:Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LABORATORY
REPRODUCTIVE TOXICOLOGY DIVISION
DEVELOPMENTAL BIOLOGY BRANCH