Science Inventory

A PHYSIOLOGICALLY BASED COMPUTATIONAL MODEL OF THE BPG AXIS IN FATHEAD MINNOWS: PREDICTING EFFECTS OF ENDOCRINE DISRUPTING CHEMICAL EXPOSURE ON REPRODUCTIVE ENDPOINTS

Citation:

WATANABE, K., Z. LI, K. KROLL, N. REYERO, N. SZABO, M. SEPULVEDA, E. ORLANDO, D. L. VILLENEUVE, M. BREEN, G. T. ANKLEY, AND N. DENSLOW. A PHYSIOLOGICALLY BASED COMPUTATIONAL MODEL OF THE BPG AXIS IN FATHEAD MINNOWS: PREDICTING EFFECTS OF ENDOCRINE DISRUPTING CHEMICAL EXPOSURE ON REPRODUCTIVE ENDPOINTS. Presented at International Science Forum on Computational Toxicology, Research Triangle Park, NC, May 21 - 23, 2007.

Description:

This presentation describes development and application of a physiologically-based computational model that simulates the brain-pituitary-gonadal (BPG) axis and other endpoints important in reproduction such as concentrations of sex steroid hormones, 17-estradiol, testosterone, and 11-ketotestosterone; and vitellogenin, a precursor to the major egg yolk protein.

Record Details:

Record Type: DOCUMENT (PRESENTATION/ABSTRACT)
Product Published Date: 05/21/2007
Record Last Revised: 06/29/2007
Record ID: 165898

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LABORATORY

MID-CONTINENT ECOLOGY DIVISION

TOXIC EFFECTS CHARACTERIZATION RESEARCH