Science Inventory

ANIMAL MODELS FOR IMMUNOTOXICITY

Citation:

LUEBKE, R. W. ANIMAL MODELS FOR IMMUNOTOXICITY. METHODS. Elsevier Science BV, Amsterdam, Netherlands, 41(1):38-47, (2007).

Impact/Purpose:

This focus of this paper is resistance to infection with the parasitic nematode Trichinella spiralis as a model of host resistance

Description:

Greater susceptibility to infection is a hallmark of compromised immune function in humans and animals, and is often considered the benchmark against which the predictive value of immune function tests are compared. This focus of this paper is resistance to infection with the parasitic nematode Trichinella spiralis as a model of host resistance. Topics include overviews of parasite biology, host immune responses that limit infection and methods used to evaluate the host response to infection. Detailed protocols are provided for adult and larval parasite counts, female parasite fecundity, parasite antigen-driven lymphocyte proliferation and antibody responses to infection.

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Product Published Date: 01/01/2007
Record Last Revised: 10/09/2008
OMB Category: Other
Record ID: 150953

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LABORATORY

EXPERIMENTAL TOXICOLOGY DIVISION

IMMUNOTOXICOLOGY BRANCH