Science Inventory

ROLE OF NMDA, NICOTINIC, AND GABA RECEPTORS IN THE STEADY STATE VISUAL EVOKED POTENTIAL IN RATS.

Citation:

BALE, A., T. ADAMS, P. J. BUSHNELL, T. J. SHAFER, AND W. K. BOYES. ROLE OF NMDA, NICOTINIC, AND GABA RECEPTORS IN THE STEADY STATE VISUAL EVOKED POTENTIAL IN RATS. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR. Elsevier Science Ltd, New York, NY, 82(4):635-645, (2006).

Impact/Purpose:

To characterize the receptor pathways involved in pattern-evoked potential generation in rats

Description:

This manuscript characterizes the receptor pathways involved in pattern-evoked potential generation in rats

" NMDA and nicotinic acetylcholine receptors appear to be involved in the generation of the steady-state pattern evoked response in vivo.

" The pattern evoked visual potential is sensitive to alteration by volatile organic compounds on the Hazardous Air Pollutants list. This data in this paper furthers our understanding of the basic neurobiology underlying this response and will facilitate examination of the mechanisms underlying effects of volatile organic compounds on this measure. These results will strengthen extrapolations across species, route and dose level by providing mechanistic data and allow for the development of in vitro tests for screening volatile organic solvents for neurotoxic effects.

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Product Published Date: 01/15/2006
Record Last Revised: 08/17/2006
OMB Category: Other
Record ID: 138225

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LABORATORY

NEUROTOXICOLOGY DIVISION

NEUROPHYSIOLOGICAL TOXICOLOGY BRANCH