Science Inventory

NEUROCHEMICAL EFFECTS OF CHRONIC DIETARY AND REPEATED HIGH-LEVEL ACUTE EXPOSURE TO CHLORPYRIFOS IN RATS.

Citation:

PADILLA, S. J., R. S. MARSHALL, D. L. HUNTER, S. OXENDINE, V. C. MOSER, S. B. SOUTHERLAND, AND R. B. MAILMAN. NEUROCHEMICAL EFFECTS OF CHRONIC DIETARY AND REPEATED HIGH-LEVEL ACUTE EXPOSURE TO CHLORPYRIFOS IN RATS. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 88(1):161-171, (2005).

Impact/Purpose:

To investigate the chronic neurotoxic effects of and organophosphorus, anticholinesterase pesticide: chlorpyrifos

Description:

Lots of information is available surrounding the acute toxicity of anticholinesterase pesticides, but these have been very few detailed studies on the chronic effects of these pesticides. Humans are exposed on a chronic basis and some humans believe that have been affected adversely. Our laboratory set out to investigate the chronic toxicity of one, commonly used organophosphorus, anticholinesterase pesticide, chlorpyrifos. Animals were given the pesticide for one year in their feed at both a high and low dose. It was found that brain chemistry was changed during dosing at the highest level, but 3 months after dosing had ceased, all the neurochemical endpoints had returned to normal

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Product Published Date: 09/01/2005
Record Last Revised: 08/17/2006
OMB Category: Other
Record ID: 134805

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LABORATORY

NEUROTOXICOLOGY DIVISION

CELLULAR AND MOLECULAR TOXICOLOGY BRANCH