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Evaluation of Gene Expression Endpoints in the Context of a Xenopus laevis Metamorphosis-based Bioassay to Detect Thyroid Hormone Disruptors
ZHANG, F., G. W. HOLCOMBE, P. A. KOSIAN, J. E. TIETGE, N. VELDHOEN, S. J. DEGITZ, JR., AND C. C. HELBING. Evaluation of Gene Expression Endpoints in the Context of a Xenopus laevis Metamorphosis-based Bioassay to Detect Thyroid Hormone Disruptors. AQUATIC TOXICOLOGY. Elsevier Science Ltd, New York, NY, 76((2006)):24-36, (2006).
To provide information required to optimize exposure regimens and endpoint assessments for detecting disruption in thyroid-regulatory systems
This study accentuates the need to examine multiple tissues and provides critical information required for optimization of exposure regimens and endpoint assessments that focus on the detection of disruption in TH-regulatory systems.
Record Details:Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LABORATORY
MID-CONTINENT ECOLOGY DIVISION
MOLECULAR & CELLULAR MECHANISMS RESEARCH