Science Inventory

Evaluation of Gene Expression Endpoints in the Context of a Xenopus laevis Metamorphosis-based Bioassay to Detect Thyroid Hormone Disruptors

Citation:

ZHANG, F., G. W. HOLCOMBE, P. A. KOSIAN, J. E. TIETGE, N. VELDHOEN, S. J. DEGITZ, JR., AND C. C. HELBING. Evaluation of Gene Expression Endpoints in the Context of a Xenopus laevis Metamorphosis-based Bioassay to Detect Thyroid Hormone Disruptors. AQUATIC TOXICOLOGY. Elsevier Science Ltd, New York, NY, 76((2006)):24-36, (2006).

Impact/Purpose:

To provide information required to optimize exposure regimens and endpoint assessments for detecting disruption in thyroid-regulatory systems

Description:

This study accentuates the need to examine multiple tissues and provides critical information required for optimization of exposure regimens and endpoint assessments that focus on the detection of disruption in TH-regulatory systems.

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Product Published Date: 02/03/2006
Record Last Revised: 11/19/2008
OMB Category: Other
Record ID: 118785

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LABORATORY

MID-CONTINENT ECOLOGY DIVISION

MOLECULAR & CELLULAR MECHANISMS RESEARCH