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ANTIOXIDANT SUPPLEMENTATION AND NASAL INFLAMMATORY RESPONSES AMONG YOUNG ASTHMATICS EXPOSED TO HIGH LEVELS OF OZONE
SienraMonge, Juan Jose, M. RAMIREZ-AGUILAR, H. MORENO-MACIAS, N. I. REYES-RUIZ, B. E. RIO-NAVARRO, M. X. RUIZ-NAVARRO, G. E. Hatch, K M. Crissman, R. Slade, R. B. Devlin, AND I. Romieu. ANTIOXIDANT SUPPLEMENTATION AND NASAL INFLAMMATORY RESPONSES AMONG YOUNG ASTHMATICS EXPOSED TO HIGH LEVELS OF OZONE. Clinical and Experimental Immunology. Blackwell Publishing Limited, Oxford, Uk, 138(2):317-322, (2004).
Objective: We aimed to investigate the impact of antioxidant supplementation on the inflammatory response of the airway due to ozone exposure in the atopic asthmatic children.
Background: Recent studies examining the inflammatory response in atopic asthma to ozone suggest a release of soluble mediators of inflammation factors that might be related to reactive oxygen species (ROS). Antioxidant could prove useful in subjects exposed to additional oxidative stress associated to photochemical oxidant pollution.
Methods: We conducted a randomized trial using a double blinded design. Children with asthma (n= 117), residents of Mexico City were randomly given a daily supplement of vitamins (50 mg/day of vitamin E and 250 mg/day of vitamin C) or placebo. Nasal lavage were performed during the 4 month of follow-up and analyzed for the content en IL-8, IL-6, uric acid and glutathione (GSH).
Results: Significant increases in IL-6 were observed in the placebo group in relation to ozone exposure while no changes were observed in the supplement group. The larger increase in IL-6 in the placebo group was observed with a 3-day lag after exposure. The difference in response to ozone exposure between the two groups was significant (p=0.01). For IL-8 we observed similar results; however the difference between groups was not significant (p=0.12). Uric acid was decreased in the placebo group after ozone exposure while no significant changes were observed in the supplement group. GSH decreased in both groups.