Science Inventory

THE ACQUISITION AND APPLICATION OF ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION (ADME) DATA IN AGRICULTURAL CHEMICAL SAFETY ASSESSMENTS

Citation:

Barton, H A., K. P. Baetcke, J. E. Chambers, J J. Diliberto, J. H. Driver, C. E. Hastings, S. Iyengar, R. Krieger, T. Pastoor, B. U. Stahl, AND C. Timchalk. THE ACQUISITION AND APPLICATION OF ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION (ADME) DATA IN AGRICULTURAL CHEMICAL SAFETY ASSESSMENTS. CRITICAL REVIEWS IN TOXICOLOGY. CRC Press LLC, Boca Raton, FL, 36(1):9-35, (2006).

Impact/Purpose:

To describe a tiered approach in which basic pharmacokinetic studies would be carried out early in the product development process for agricultural chemicals

Description:

A multi-sector international group of government, academic, and industry scientists has developed a proposal for an improved testing scheme for assessing the safety of crop protection chemicals. Incorporation of pharmacokinetic studies describing the absorption, distribution, metabolism, and elimination is an essential tool for improving the design and interpretation of toxicity studies and their application for safety assessment. A tiered approach is described in which basic pharmacokinetic studies, similar to those for pharmaceuticals, would be carried out early in the product development process. Subsequent tiers would obtain additional information in an iterative manner as appropriate given pharmacokinetic properties, toxicity study results, and the intended uses of the compound.

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Product Published Date: 01/01/2006
Record Last Revised: 08/08/2006
OMB Category: Other
Record ID: 104956

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LABORATORY

EXPERIMENTAL TOXICOLOGY DIVISION

PHARMACOKINETICS BRANCH