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THE ACQUISITION AND APPLICATION OF ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION (ADME) DATA IN AGRICULTURAL CHEMICAL SAFETY ASSESSMENTS
Barton, H A., K. P. Baetcke, J. E. Chambers, J J. Diliberto, J. H. Driver, C. E. Hastings, S. Iyengar, R. Krieger, T. Pastoor, B. U. Stahl, AND C. Timchalk. THE ACQUISITION AND APPLICATION OF ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION (ADME) DATA IN AGRICULTURAL CHEMICAL SAFETY ASSESSMENTS. CRITICAL REVIEWS IN TOXICOLOGY. CRC Press LLC, Boca Raton, FL, 36(1):9-35, (2006).
To describe a tiered approach in which basic pharmacokinetic studies would be carried out early in the product development process for agricultural chemicals
A multi-sector international group of government, academic, and industry scientists has developed a proposal for an improved testing scheme for assessing the safety of crop protection chemicals. Incorporation of pharmacokinetic studies describing the absorption, distribution, metabolism, and elimination is an essential tool for improving the design and interpretation of toxicity studies and their application for safety assessment. A tiered approach is described in which basic pharmacokinetic studies, similar to those for pharmaceuticals, would be carried out early in the product development process. Subsequent tiers would obtain additional information in an iterative manner as appropriate given pharmacokinetic properties, toxicity study results, and the intended uses of the compound.
Record Details:Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LABORATORY
EXPERIMENTAL TOXICOLOGY DIVISION