Science Inventory

A DRIED BLOOD SPOT METHOD TO EVALUATE CHOLINESTERASE ACTIVITY IN YOUNG CHILDREN

Citation:

Hilborn, E D. AND S J. Padilla. A DRIED BLOOD SPOT METHOD TO EVALUATE CHOLINESTERASE ACTIVITY IN YOUNG CHILDREN. ARCHIVES OF ENVIRONMENTAL HEALTH. Heldref Publications, 59(9):467-470, (2005).

Impact/Purpose:

To develop better field methods to detect and monitor anticholinesterase pesticide exposure of young children

Description:

Field methods are needed to detect and monitor anticholinesterase pesticide exposure of young children. Twenty children, aged 11-18 months, living in an agricultural community along the US/Mexico border were enrolled in a pilot study investigating methods to detect pesticide exposure. Children were recruited at health care clinics with the informed consent of their parent. Venous blood samples were collected from children twice, four weeks apart. Cholinesterase activity was compared in whole heparinized venous blood and venous blood samples dried on filter paper. Although the amount of activity in the dried blood was consistently less than the venous blood, the activity was significantly correlated: Spearman r2=0.6 (p=0.01). This dried blood method may be used during field studies to evaluate cholinesterase values in children. The views expressed in this report are those of the individual authors and do not necessarily reflect the views and policies of the U.S. Environmental Protection Agency. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Product Published Date: 12/01/2005
Record Last Revised: 07/14/2008
OMB Category: Other
Record ID: 104880

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LABORATORY

HUMAN STUDIES DIVISION

EPIDEMIOLOGY AND BIOMARKERS BRANCH