You are here:
USE OF TROUT LIVER SLICES TO ENHANCE MECHANISTIC INTERPRETATION OF ER BINDING FOR COST-EFFECTIVE PRIORITIZATION OF CHEMICALS WITHIN LARGE INVENTORIES
Citation:
Schmieder, P. K., M A. Tapper, J. S. Denny, R C. Kolanczyk, B R. Sheedy, T. R. Henry, AND G D. Veith. USE OF TROUT LIVER SLICES TO ENHANCE MECHANISTIC INTERPRETATION OF ER BINDING FOR COST-EFFECTIVE PRIORITIZATION OF CHEMICALS WITHIN LARGE INVENTORIES. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, 38(23):6333-6342, (2004).
Impact/Purpose:
to improve prioritization of chemicals for further testing
Description:
The cost of testing chemicals as reproductive toxicants precludes the possibility of evaluating large chemical inventories without a robust strategic approach for setting priorities. The use of quantitative structure-activity relationships (QSARs) in early hazard identification may be one of the most cost-effective screening approaches, but, in the absence of systematic databases, these techniques only narrow the focus of potetial hazardous chemicals. . . The collection and use of empirical information for iterative QSAR development for large chemical inventories to achieve risk assessment goals is presented and discussed.