Science Inventory

MODELING DEPOSITION OF INHALED PARTICLES

Citation:

Martonen, T B., J. A. Rosati, AND K K. Isaacs. MODELING DEPOSITION OF INHALED PARTICLES. Chapter 8, L.S. Ruzer and N.H. Harley (ed.), Aerosols Handbook: Measurement, Dosimetry, and Health Effects. CRC Press LLC, Boca Raton, FL, , 113-155, (2005).

Impact/Purpose:

To review the basic engineering theory and respiratory morphology required for deposition modeling

Description:

Modeling Deposition of Inhaled Particles: ABSTRACT

The mathematical modeling of the deposition and distribution of inhaled aerosols within human lungs is an invaluable tool in predicting both the health risks associated with inhaled environmental aerosols and the therapeutic dose delivered by inhaled pharmacological drugs. However, mathematical modeling of aerosol deposition requires knowledge of the intricate geometry of the respiratory network and the resulting complex motion of air and particles within the airways. In this chapter, an overview of the basic engineering theory and respiratory morphology required for deposition modeling are covered. Furthermore, current deposition modeling approaches are reviewed, and many factors affecting deposition are discussed. Experimental methods for measuring lung deposition are presented, albeit briefly, and the comparison between experimental results and modeling predictions are examined for a selection of modeling efforts.

Record Details:

Record Type: DOCUMENT (BOOK CHAPTER)
Product Published Date: 07/26/2004
Record Last Revised: 07/21/2006
OMB Category: Other
Record ID: 103984

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LABORATORY

EXPERIMENTAL TOXICOLOGY DIVISION

IMMEDIATE OFFICE