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MODELING DEPOSITION OF INHALED PARTICLES
Martonen, T B., J. A. Rosati, AND K K. Isaacs. MODELING DEPOSITION OF INHALED PARTICLES. Chapter 8, L.S. Ruzer and N.H. Harley (ed.), Aerosols Handbook: Measurement, Dosimetry, and Health Effects. CRC Press LLC, Boca Raton, FL, , 113-155, (2005).
To review the basic engineering theory and respiratory morphology required for deposition modeling
Modeling Deposition of Inhaled Particles: ABSTRACT
The mathematical modeling of the deposition and distribution of inhaled aerosols within human lungs is an invaluable tool in predicting both the health risks associated with inhaled environmental aerosols and the therapeutic dose delivered by inhaled pharmacological drugs. However, mathematical modeling of aerosol deposition requires knowledge of the intricate geometry of the respiratory network and the resulting complex motion of air and particles within the airways. In this chapter, an overview of the basic engineering theory and respiratory morphology required for deposition modeling are covered. Furthermore, current deposition modeling approaches are reviewed, and many factors affecting deposition are discussed. Experimental methods for measuring lung deposition are presented, albeit briefly, and the comparison between experimental results and modeling predictions are examined for a selection of modeling efforts.
Record Details:Record Type: DOCUMENT (BOOK CHAPTER)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LABORATORY
EXPERIMENTAL TOXICOLOGY DIVISION