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IDENTIFICATION OF TIME-INTEGRATED SAMPLING AND MEASUREMENT TECHNIQUES TO SUPPORT HUMAN EXPOSURE STUDIES
McKinney, J. D., S N. Hern, AND G L. Robertson. IDENTIFICATION OF TIME-INTEGRATED SAMPLING AND MEASUREMENT TECHNIQUES TO SUPPORT HUMAN EXPOSURE STUDIES. U.S. Environmental Protection Agency, Washington, DC, EPA/600/R-04/043 (NTIS PB2004-105639), 2004.
The objective of this task is to identify, develop, and evaluate simple, cost effective monitoring methods that can be used to develop exposure classifications for the proposed Longitudinal Cohort Study. Methods once evaluated should be applicable to other epidemiological studies. This project will be conducted as four concurrent subprojects.
(1) demonstrating field performance and developing uptake rates of a semipermeable membrane devise (SMPD) to collect long-term integrated samples for semivolatile organics in air,
(2) developing simple rapid methods for analyzing the SMPDs,
(3) developing rapid field or near field methods for analyzing chemical metabolites in urine,
(4) review literature to identify available but not currently used techniques for long-term integrated exposure measurements.
Accurate exposure classification tools are required to link exposure with health effects in epidemiological studies. Long-term, time-integrated exposure measures would be desirable to address the problem of developing appropriate residential childhood exposure classifications. Screening techniques are also of interest that could focus attention on the most highly exposed (to indicator compounds) populations for which costly multiroute, multimedia monitoring would be most informative. This report presents the results of a literature review that was designed to investigate and/or evaluate methods used in classifying exposure, both long-term, time-integrated and screening methods for assessing exposures to relatively short half-life contaminants.
The information in this document has been funded and managed by the United States Environmental Protection Agency under Contract 68-D-99-012 to Research Triangle Institute. It has been subjected to the Agency's peer and administrative review and has been approved for publication as an EPA document. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.