Science Inventory

Draft Genome Sequence of Mycobacterium chimaera Type Strain Fl-0169

Citation:

Pfaller, S., V. Tokarev, C. Kessler, C. McLimans, V. Gomez-Alvarez, J. Wright, D. King, AND R. Lamendella. Draft Genome Sequence of Mycobacterium chimaera Type Strain Fl-0169. Genome Announcements. American Society for Microbiology, Washington, DC, 5(8):e01620-16, (2017).

Impact/Purpose:

Evidence suggests that M. avium, M. intracellulare, and M. chimaera are differently virulent and a comparative genomic analysis is critically needed to identify diagnostic targets that reliably differentiate species of MAC. With treatment costs for Mycobacterium infections estimated to be >$1.8 B annually in the U.S., correct species identification will result in improved treatment selection, lower costs, and improved patient outcomes.

Description:

We report the draft genome sequence of the type strain Mycobacterium chimaera Fl-0169T, a member of the Mycobacterium avium complex (MAC). M. chimaera Fl-0169T was isolated from a patient in Italy and is highly similar to strains of M. chimaera isolated in Ireland, though Fl-0169T possesses unique virulence genes.

URLs/Downloads:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323614/   Exit

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Product Published Date: 02/23/2017
Record Last Revised: 05/08/2017
OMB Category: Other
Record ID: 336240

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL EXPOSURE RESEARCH LABORATORY

SYSTEMS EXPOSURE DIVISION

ENVIRONMENTAL FUTURES ANALYSIS BRANCH