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The Role of Arsenic Speciation in Dietary Exposure Assessment and the Need to Include Bioaccessibility and Biotransformation
Creed, J., P. Creed, T. Pinyayev, M. Mantha, J. Trent, E. Yeary, J. Xue, M. Kohan, K. Herbin-Davis, D. Thomas, K. Kubachka, T. Hanley, N. Shockey, D. Heitkemper, AND J. Caruso. The Role of Arsenic Speciation in Dietary Exposure Assessment and the Need to Include Bioaccessibility and Biotransformation. Presented at 245th ACS National Meeting & Exposition, New Orleans, LA, April 07 - 11, 2013.
To give an invited lecture at the spring ACS conference
Chemical form specific exposure assessment for arsenic has long been identified as a source of uncertainty in estimating the risk associated with the aggregate exposure for a population. Some speciation based assessments document occurrence within an exposure route; however, the risk predictive capability is limited without a physiological relevant estimate of the exposure. The use of a speciation based gastrointestinal (GI) assay as a means to estimate the bioaccessibility of arsenicals in rice will be discussed. This assay establishes the variability of inorganic arsenic in rice consumed by the US population and facilitates the use of a model to generate µg/kg of body weight/day estimates. Secondly, the exposure implications associated with the biotransformation of the ingested parent arsenic oxide by the microbes (derived from mouse cecum) in the GI tract prior to the intestine will be discussed. The results from these incubation studies will be presented with an emphasis on their exposure assessment implications.
Record Details:Record Type: DOCUMENT (PRESENTATION/SLIDE)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL EXPOSURE RESEARCH LABORATORY
MICROBIOLOGICAL AND CHEMICAL EXPOSURE ASSESSMENT DIVISION
CHEMICAL EXPOSURE RESEARCH BRANCH