Science Inventory

The Role of Arsenic Speciation in Dietary Exposure Assessment and the Need to Include Bioaccessibility and Biotransformation

Citation:

Creed, J., P. Creed, T. Pinyayev, M. Mantha, J. Trent, E. Yeary, J. Xue, M. Kohan, K. Herbin-Davis, D. Thomas, K. Kubachka, T. Hanley, N. Shockey, D. Heitkemper, AND J. Caruso. The Role of Arsenic Speciation in Dietary Exposure Assessment and the Need to Include Bioaccessibility and Biotransformation. Presented at 245th ACS National Meeting & Exposition, New Orleans, LA, April 07 - 11, 2013.

Impact/Purpose:

To give an invited lecture at the spring ACS conference

Description:

Chemical form specific exposure assessment for arsenic has long been identified as a source of uncertainty in estimating the risk associated with the aggregate exposure for a population. Some speciation based assessments document occurrence within an exposure route; however, the risk predictive capability is limited without a physiological relevant estimate of the exposure. The use of a speciation based gastrointestinal (GI) assay as a means to estimate the bioaccessibility of arsenicals in rice will be discussed. This assay establishes the variability of inorganic arsenic in rice consumed by the US population and facilitates the use of a model to generate µg/kg of body weight/day estimates. Secondly, the exposure implications associated with the biotransformation of the ingested parent arsenic oxide by the microbes (derived from mouse cecum) in the GI tract prior to the intestine will be discussed. The results from these incubation studies will be presented with an emphasis on their exposure assessment implications.

Record Details:

Record Type: DOCUMENT (PRESENTATION/SLIDE)
Product Published Date: 04/11/2013
Record Last Revised: 02/16/2016
OMB Category: Other
Record ID: 259412

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL EXPOSURE RESEARCH LABORATORY

MICROBIOLOGICAL AND CHEMICAL EXPOSURE ASSESSMENT DIVISION

CHEMICAL EXPOSURE RESEARCH BRANCH