Science Inventory

Parameters for Pyrethroid Insecticide QSAR and PBPK/PD Models for Human Risk Assessment

Citation:

KNAAK, J. B., C. C. DARY, X. Zhang, R. W. Gerlach, R. TORNERO-VELEZ, D. CHANG, M. GOLDSMITH, AND J. N. BLANCATO. Parameters for Pyrethroid Insecticide QSAR and PBPK/PD Models for Human Risk Assessment . Chapter INT, Springer, New York, NY, 219:1-114, (2012).

Impact/Purpose:

The National Exposure Research Laboratory′s (NERL′s) Human Exposure and Atmospheric Sciences Division (HEASD) conducts research in support of EPA′s mission to protect human health and the environment. HEASD′s research program supports Goal 1 (Clean Air) and Goal 4 (Healthy People) of EPA′s strategic plan. More specifically, our division conducts research to characterize the movement of pollutants from the source to contact with humans. Our multidisciplinary research program produces Methods, Measurements, and Models to identify relationships between and characterize processes that link source emissions, environmental concentrations, human exposures, and target-tissue dose. The impact of these tools is improved regulatory programs and policies for EPA.

Description:

This pyrethroid insecticide parameter review is an extension of our interest in developing quantitative structure–activity relationship–physiologically based pharmacokinetic/pharmacodynamic (QSAR-PBPK/PD) models for assessing health risks, which interest started with the organophosphorus (OP) and carbamate insecticides (Knaak et al. 2004, 2008). The parameters shown in Table 1 (Blancato et al. 2000) are needed for developing pyrethroid PBPK/PD models, as is information on the metabolic pathways of specific pyrethroids in laboratory test animals and humans. Parameters may be obtained by fitting the output from models to experimental data gathered from in vivo studies (Zhang et al. 2007; Nong et al. 2008), in conjunction with using (1) experimental data obtained from in vitro studies, (2) quantitative structure–activity relationships (QSAR) and (3) other mathematical models, such as the mechanistic Poulin-Theil (2000; 2002a; b) algorithms for obtaining blood:tissue partition coefficients.

URLs/Downloads:

Parameters for Pyrethroid Insecticide QSAR and PBPK/PD Models for Human Risk Assessment   (PDF,NA pp, 536 KB,  about PDF)

Record Details:

Record Type: DOCUMENT (BOOK CHAPTER)
Product Published Date: 06/22/2012
Record Last Revised: 09/10/2012
OMB Category: Other
Record ID: 241805

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL EXPOSURE RESEARCH LABORATORY

HUMAN EXPOSURE AND ATMOSPHERIC SCIENCES DIVISION

EXPOSURE & DOSE RESEARCH BRANCH