Science Inventory

IRIS Toxicological Review of n-Butanol (External Review Draft)


EPA has released the Toxicological Review of n-Butanol (External Review Draft) for public review and comment. EPA has reopened the public comment period, announced in the November 16, 2011, Federal Register Notice until December 7, 2011.


U.S. EPA. IRIS Toxicological Review of n-Butanol (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-11/081A, 2011.


EPA is undertaking an Integrated Risk Information System (IRIS) health assessment for n-butanol. IRIS is an EPA database containing Agency scientific positions on potential adverse human health effects that may result from chronic (or lifetime) exposure to chemicals in the environment. IRIS contains chemical-specific summaries of qualitative and quantitative health information in support of two steps of the risk assessment paradigm, i.e., hazard identification and dose-response evaluation. IRIS assessments are used in combination with specific situational exposure assessment information to evaluate potential public health risk associated with environmental contaminants.


EPA is conducting a peer review of the scientific basis supporting the human health hazard and dose-response assessment of n-butanol that will appear in the Integrated Risk Information System (IRIS) database.


FR Notice: Nov 16, 2011   Exit

FR Notice: Aug 31, 2011   Exit

Peer Review Plan   (PDF,NA pp, 33 KB,  about PDF)

FR Notice: Sep 15, 2011   Exit

Charge to External Peer Reviewers   (PDF,3 pp, 29 KB,  about PDF)

IRIS Toxicological Review of n-Butanol (External Review Draft)   (PDF,136 pp, 904 KB,  about PDF)

Record Details:

Product Published Date: 08/31/2011
Record Last Revised: 03/25/2019
OMB Category: Other
Record ID: 200321