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Chemical Mixtures Health Risk Assessment of Environmental Contaminants: Concepts, Methods, And Applications
Rice, G. AND Jeff Swartout. Chemical Mixtures Health Risk Assessment of Environmental Contaminants: Concepts, Methods, And Applications. Toxicology and Risk Assessment Conference, Cincinnati, OH, April 23 - 26, 2018.
The attached materials will support a problems-based, introductory workshop that focuses on methods to assess health risks posed by exposures to chemical mixtures in the environment. The workshop will be held at the Toxicology and Risk Assessment Conference.
This problems-based, introductory workshop focuses on methods to assess health risks posed by exposures to chemical mixtures in the environment. Chemical mixtures health risk assessment methods continue to be developed and evolve to address concerns over health risks from multichemical exposures. This workshop presents key concepts and terminology used in chemical mixtures risk assessment. The course discusses component methods that utilize assumptions of response addition and dose addition, including the following dose-additive methods: the hazard index, interaction-based hazard index, relative potency factors, and toxicity equivalence factors; integrated additivity methods also will be described. There will also be a short discussion of whole mixtures risk assessment, including the development of reference doses and slope factors from whole mixtures toxicity data, and the potential uses of 21st century toxicity data in mixtures risk assessment. The risk assessment examples developed in the workshop are adapted from real-world mixture analyses, e.g., waste site contaminants, pesticide applications, and drinking water disinfection by-product exposures. The “hands-on” exercises demonstrating the methods are an essential part of this workshop. Discussions include real world examples, exercise results, and answers to general questions. (We ask participants to bring a calculator or laptop). The views expressed in this abstract are those of the authors and do not necessarily reflect the views or policies of the USEPA.
Record Details:Record Type: DOCUMENT (PRESENTATION/SLIDE)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL CENTER FOR ENVIRONMENTAL ASSESSMENT
CHEMICAL RISK ASSESSMENT BRANCH