Science Inventory

IRIS Assessment Plan for Uranium (Scoping and Problem Formulation Materials)

Notice:

EPA released the IRIS Assessment Plan for Uranium (Oral Reference Dose) (Scoping and Problem Formulation Materials) for a 30-day public comment period. Information regarding the implementation of systematic review in the IRIS Program is described in a January 2018 Memo. EPA hosted an IRIS Public Science Meeting (Webinar Only) to discuss this chemical on March 22, 2018.

Citation:

U.S. EPA. IRIS Assessment Plan for Uranium (Scoping and Problem Formulation Materials). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-17/787, 2018.

Impact/Purpose:

The IAP communicates to the public the plan for assessing each individual chemical and includes summary information on the IRIS Program’s scoping and initial problem formulation, objectives and specific aims for the assessment, and a PECO framework that outlines the evidence considered most pertinent to the assessment; and identification of key areas of scientific complexity.

Description:

In January 2018, EPA released the IRIS Assessment Plan for Uranium (Oral Reference Dose) (Scoping and Problem Formulation Materials). An IRIS Assessment Plan (IAP) communicates to the public the plan for assessing each individual chemical and includes summary information on the IRIS Program’s scoping and initial problem formulation; objectives and specific aims for the assessment; the PECO (Populations, Exposures, Comparators, and Outcomes) criteria that outlines the evidence considered most pertinent to the assessment; and identification of key areas of scientific complexity. The PECO provides the framework for developing literature search strategies and inclusion/exclusion criteria, particularly with respect to evidence stream (i.e., human, animal, mechanistic), exposure measures and outcome measures.

Record Details:

Record Type: DOCUMENT (IRIS ASSESSMENT)
Record Released: 01/22/2018
Record Last Revised: 05/24/2018
OMB Category: Influential
Record ID: 338655