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IRIS Toxicological Review of Hexavalent Chromium Part 2: Human, Toxicokinetic, and Mechanistic Studies (Preliminary Assessment Materials)
EPA hosted an IRIS public science meeting on October 29-30, 2014, to provide an opportunity for the public to give input and participate in an open discussion regarding preliminary materials that were prepared for the IRIS chemicals, hexavalent chromium (Cr(VI)) and diisononyl phthalate (DINP), prior to the development of the draft assessment.
U.S. EPA. IRIS Toxicological Review of Hexavalent Chromium Part 2: Human, Toxicokinetic, and Mechanistic Studies (Preliminary Assessment Materials). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-14/218, 2014.
This material is the second of two preliminary packages being released for public viewing and comment prior to a public meeting, providing an opportunity for the IRIS Program to engage in early discussions with stakeholders and the public on data that may be used to identify adverse health effects and characterize exposure-response relationships. EPA welcomes all comments on the draft literature search, preliminary human evidence tables, and preliminary toxicokinetic and mechanistic study information, such as remarks on the following: • the clarity and transparency of the materials; • the approach for identifying pertinent studies; • the selection of studies for data extraction to preliminary human evidence tables; • any methodological considerations that could affect the interpretation of or confidence in study results; and • any additional studies published or nearing publication that may provide data for the evaluation of human health hazard or dose-response relationships.
In August 2014, EPA released the second part of draft literature searches and associated search strategies, evidence tables, and exposure response arrays for Cr(VI) to obtain input from stakeholders and the public prior to developing the draft IRIS assessment. Specifically, EPA was interested in comments on the following:
- Draft literature search strategies
- The approach for identifying studies
- The screening process for selecting pertinent studies
- The resulting list of pertinent studies
- Preliminary evidence tables
- The process for selecting studies to include in evidence tables
- The quality of the studies in the evidence tables
URLs/Downloads:Literature selection process for the Cr(VI) primary literature
Scoping information, preliminary literature search, associated strategy and evidence tables for Cr(VI) - Part 2. (PDF,98 pp, 2160 KB, about PDF)
Primary literature search references sorted by author (Cr(VI))
IRIS October 2014 Meeting & Presentations
Record Details:Record Type: DOCUMENT (IRIS ASSESSMENT)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL CENTER FOR ENVIRONMENTAL ASSESSMENT
OFFICE OF THE DEPUTY DIRECTOR