Science Inventory

Advances in Inhalation Gas Dosimetry for Derivation of a Reference Concentration (RfC) and Use in Risk Assessment

Notice:

The U.S. EPA has released the final status report entitled Advances in Inhalation Gas Dosimetry for Derivation of a Reference Concentration (RfC) and Use in Risk Assessment.

Citation:

U.S. EPA. Advances in Inhalation Gas Dosimetry for Derivation of a Reference Concentration (RfC) and Use in Risk Assessment. U.S. Environmental Protection Agency, Washington, DC, EPA/600/R-12/044, 2012.

Impact/Purpose:

This report was written to evaluate the state of the science and advances in gas dosimetry that have occurred since the publication of the 1994 RfC Methods. In addition, the state of the science considering children’s inhalation dosimetry is also addressed. It was also written in response to concerns and questions about the methods that NCEA has received from external peer reviewers of IRIS documents, and other client program offices as well as regional and state agencies.

Description:

This status report provides a review of advances in the state of the science for interspecies inhalation gas dosimetry related to extrathoracic (ET) or upper respiratory tract (URT), tracheobronchial (TB), pulmonary (PU), and extrarespiratory (systemic, SYS) effects.

URLs/Downloads:

IRIS Web site

Advances in Inhalation Gas Dosimetry for Derivation of a Reference Concentration (RfC) and Use in Risk Assessment   (PDF,145 pp, 2287 KB,  about PDF)

Record Details:

Record Type: DOCUMENT (PUBLISHED REPORT/REPORT)
Product Published Date: 09/28/2012
Record Last Revised: 12/14/2012
OMB Category: Influential
Record ID: 244650

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL CENTER FOR ENVIRONMENTAL ASSESSMENT

RESEARCH TRIANGLE PARK NC

HAZARDOUS POLLUTANT ASSESSMENT GROUP