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IRIS Toxicological Review of Tetrahydrofuran (THF) (Interagency Science Discussion Draft)
U.S. EPA. IRIS Toxicological Review of Tetrahydrofuran (THF) (Interagency Science Discussion Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-11/006D, 2011.
EPA is undertaking an Integrated Risk Information System (IRIS) health assessment for tetrahydrofuran. IRIS is an EPA database containing Agency scientific positions on potential adverse human health effects that may result from chronic (or lifetime) exposure to chemicals in the environment. IRIS contains chemical-specific summaries of qualitative and quantitative health information in support of two steps of the risk assessment paradigm, i.e., hazard identification and dose-response evaluation. IRIS assessments are used in combination with specific situational exposure assessment information to evaluate potential public health risk associated with environmental contaminants.
EPA is releasing the draft report, Toxicological Review of Tetrahydrofuran, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from other Federal agencies and White House Offices are provided below with external peer review panel comments.
URLs/Downloads:EPA's Response & Interagency Science Discussion Comments (PDF,6 pp, 201 KB, about PDF)
IRIS Toxicological Review of Tetrahydrofuran (Interagency Science Discussion Draft) (PDF,193 pp, 1145 KB, about PDF)
2. OMB Office of Information and Regulatory Affairs THF IASD Comments (PDF,5 pp, 211 KB, about PDF)
1. CDC ATSDR THF IASD Comments (PDF,1 pp, 22 KB, about PDF)
IRIS Summary for Tetrahydrofuran (Interagency Science Discussion Draft) (PDF,20 pp, 156 KB, about PDF)
3. NIEHS National Toxicology Program THF IASD Comments (PDF,1 pp, 32 KB, about PDF)