Science Inventory

Pathophysiological Progression Model for Selected Toxicological Endpoints

Citation:

PAGAN, I., L. T. HABER, AND D. G. Dodge. Pathophysiological Progression Model for Selected Toxicological Endpoints. Presented at Society for Toxicologic Pathology Annual Meeting, San Francisco, CA, June 22 - 26, 2008.

Impact/Purpose:

The goal of this project is to to organize, integrate and present toxicological data into existing continuum paradigm frameworks that characterize endpoints from no effect-to- adversity

Description:

The existing continuum paradigms are effective models to organize toxicological data associated with endpoints used in human health assessments. A compendium of endpoints characterized along a pathophysiological continuum would serve to: weigh the relative importance of effects observed across chemicals, determination of species sensitivities and human relevance, serve as reference source for chemical-mode of action (MOA) characterization. The evaluation and organization of data that are both generic to the endpoint and chemical-specific may help in the characterization of the pathophysiological continuum of chemicals acting via similar pathways. Considering more than one framework (Schulte paradigm, and NRC model) will allow for the addition of events not considered in the traditional continuum framework (e.g. disruption of homeostatic controls)

Record Details:

Record Type: DOCUMENT (PRESENTATION/POSTER)
Product Published Date: 06/23/2008
Record Last Revised: 11/25/2008
OMB Category: Other
Record ID: 194805

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL CENTER FOR ENVIRONMENTAL ASSESSMENT

RESEARCH TRIANGLE PARK NC

HAZARDOUS POLLUTANT ASSESSMENT GROUP