Science Inventory

Development of a Relative Potency Factor (Rpf) Approach for Polycyclic Aromatic Hydrocarbon (PAH) Mixtures (External Review Draft)

Notice:

EPA is announcing a 60-day public comment period and a public listening session for the external review draft document titled, Development of a Relative Potency Factor (RPF) Approach for Polycyclic Aromatic Hydrocarbon (PAH) Mixtures (External Review Draft), as announced in the February 26, 2010 Federal Register Notice.

Citation:

U.S. EPA. Development of a Relative Potency Factor (Rpf) Approach for Polycyclic Aromatic Hydrocarbon (PAH) Mixtures (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-08/012A, 2010.

Impact/Purpose:

The draft Relative Potency Factor approach is not a reassessment of individual PAH carcinogenicity, but rather provides a cancer risk estimate for PAH mixtures by summing doses of component PAHs after scaling the doses (with RPFs) relative to the potency of an index PAH (i.e., benzo[a]pyrene). The cancer risk is then estimated using the dose-response curve for the index PAH.

Description:

EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of polycyclic aromatic hydrocarbon (PAH) mixtures that when finalized will appear on the Integrated Risk Information System (IRIS) database.

URLs/Downloads:

IRIS_PAH_RPF_ERD.PDF   (PDF,622 pp, 7305 KB,  about PDF)

SAB Project Page for Polycyclic Aromatic Hydrocarbon (PAH) Mixtures Review Panel

SAB Review of EPA's   (PDF,47 pp, 696 KB,  about PDF)

FR Notice: Feb 26, 2010   Exit

Draft (9/08/10) SAB Review of EPA's "Development of a Relative Potency Factor (RPF) Approach for Polycyclic Aromatic Hydrocarbon (PAH) Mixtures"   (PDF,40 pp, 512 KB,  about PDF)

Charge to External Reviewers   (PDF,5 pp, 80 KB,  about PDF)

Record Details:

Record Type: DOCUMENT (IRIS ASSESSMENT)
Product Published Date: 01/29/2010
Record Last Revised: 12/06/2016
OMB Category: Other
Record ID: 194584

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL CENTER FOR ENVIRONMENTAL ASSESSMENT

IMMEDIATE OFFICE

INTEGRATED RISK INFORMATION STAFF