You are here:
IRIS Assessment Plan for Uranium (Scoping and Problem Formulation Materials)
Citation:
U.S. EPA. IRIS Assessment Plan for Uranium (Scoping and Problem Formulation Materials). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-17/787, 2018.
Impact/Purpose:
The IAP communicates to the public the plan for assessing each individual chemical and includes summary information on the IRIS Program’s scoping and initial problem formulation, objectives and specific aims for the assessment, and a PECO framework that outlines the evidence considered most pertinent to the assessment; and identification of key areas of scientific complexity.
Description:
In January 2018, EPA released the IRIS Assessment Plan for Uranium (Oral Reference Dose) (Scoping and Problem Formulation Materials). An IRIS Assessment Plan (IAP) communicates to the public the plan for assessing each individual chemical and includes summary information on the IRIS Program’s scoping and initial problem formulation; objectives and specific aims for the assessment; the PECO (Populations, Exposures, Comparators, and Outcomes) criteria that outlines the evidence considered most pertinent to the assessment; and identification of key areas of scientific complexity. The PECO provides the framework for developing literature search strategies and inclusion/exclusion criteria, particularly with respect to evidence stream (i.e., human, animal, mechanistic), exposure measures and outcome measures.
URLs/Downloads:
IRIS Assessment Plan for Uranium (Oral Reference Dose) (Scoping and Problem Formulation Materials) (PDF, 16 pp, 330 KB, about PDF)Primary Literature Search References Sorted By Author (Uranium)
FR Notice: Feb 16, 2018
FR Notice: Jan 31, 2018
Docket for EPA-HQ-ORD-2017-0747